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Sunday, October 25, 2020

Fundamental Longevity Supplements

Longevity Supplements

This is an overview of the supplements that I am currently taking on a daily/weekly basis.

→ Last updated on October 29, 2023.

The list below is not always fully comprehensive since I am constantly trying new supplements and keep experimenting based on the latest research, experience reports from other people interested in this topic, and so forth. However, after several years of exploring various approaches and combinations, this plan is what I currently follow to serve as a consistent baseline.

Most recently, starting early 2022, I became interested in nootropics, generally as a topic and trying them out to observe their effects on myself. I've been taking a supplement containing various nootropics for about 18 months now and my experience has been positive. As a result, I added it to my regular regiment in addition to some cleansing substances that can help maintain a healthy liver.

On a high level, my intention is for these supplements to serve as a foundation for longevity, help ward off aging related illnesses, keep my body & mind operating at peak performance, and increase my personal health span.

I have divided taking these supplements into a morning and evening routine. Some of them have stimulating properties and I found them to be better taken in the morning to help with my energy levels throughout the day and to not interfere with my ability to fall asleep. Others I prefer to take in the evening to help my body perform regenerative and rejuvenating functions while I'm sleeping. I usually also go weight lifting in the gym in the evening, 3-4 times a week, shortly after taking those supplements at around 8pm.

Weekly Schedule

Broken down by weekday, this is what my schedule currently looks like.

In the spirit of cost effectiveness and manageability, I consider the number of supplements here close to the upper limit that I am willing to take on a regular basis - at this point, if I were to add something else to take on a regular basis, I would probably be trying to replace something.

Supplement Plan


Supplement Overview & Products

Below is a brief overview of the individual items on the list, as well as my product of choice for each of them. Some of these products, such as a multivitamin, are fairly straight forward and mostly self-explanatory. Others, such as pterostilbene or NR/NMN, require a more comprehensive discussion. However, in the interest of keeping this in the format of a brief overview and about related products, I'm not going into too much detail on each of these below. There are links to individual, researched, in-depth articles with additional information about each of the substances that I am taking. I only mention products on this page that I'm using myself on a regular basis and that I genuinely believe in:

Lastly, please note that I am not a doctor and only talk about my personal experience and opinion. Nothing here is medical advice and what works for me might not work for you. Please make sure to always consult your primary care physician about any information obtained from or through my site.

If you decide to purchase anything through iHerb, you can use the coupon code AMQ0238 for a 10% discount.




Multivitamin

The history of multivitamins dates back to the early 20th century when scientists identified and isolated various vitamins essential for good health. Initially, (multi-)vitamin supplements were designed to address specific nutrient deficiencies, primarily in vulnerable populations. These days, they have evolved into a culmination of various vitamins and minerals within a single dose and have become a foundational aspect of modern nutrition. In the United States, for instance, studies have shown that roughly one-third of adults report taking a multivitamin regularly.

While a balanced diet should ideally provide most necessary nutrients on a regular basis, various factors such as lifestyle, dietary preferences, physical and/or mental exertion, or even a rigorous workout plan can lead to nutritional gaps. A multivitamin supplement offers a broad spectrum of essential vitamins and minerals that the body requires for various functions, serving as my backup plan to ensure adequate intake when natural dietary sources aren't sufficient. The product that I am currently taking goes beyond a basic multivitamin and includes various compounds thought to be overall beneficial for men's health and was specifically designed for physically active individuals like myself.

In-depth article and information: Multivitamin Supplements and Longevity.

Allmax Nutrition, VITAFORM After trying countless multivitamins, including combinations of multiple products, I have now settled on VITAFORM from Allmax Nutrition as my product of choice. However, because I primarily see this as my nutrient insurance policy, I only take one of them every morning instead of the recommended serving size of two.




Nicotinamide Riboside/Mononucleotide

NAD is an essential building block during energy production. But we lose up to 50% of our NAD levels between the ages of 40 and 60. Scientists have known about the important role of NAD since 1906. Since then, they’ve learned that NAD is found in every living cell, and that it fuels the mitochondria, which keeps almost every tissue in the body healthy.

In 1963, Chambon, Weill, and Mandel reported that nicotinamide mononucleotide (NMN) provided the energy needed to activate an important nuclear enzyme. This discovery paved the way for a series of remarkable discoveries on a type of protein called a PARP. PARPs play crucial roles in repairing DNA damage, regulating cell death, and whose activity is associated with changes in lifespan.

In 1976, Dr. Martin Rechsteiner and his colleagues found convincing evidence NAD+ seemed likely to have "some other major function" in mammalian cells, beyond its classical biochemical role as an energy transfer molecule. This discovery made it possible for Dr. Leonard Guarente and his colleagues to discover that proteins called sirtuins use NAD to extend lifespan by differentially keeping some genes inactive.

In 2004, a landmark study by Dr. Charles Brenner discovered that a unique form of vitamin B3 called nicotinamide riboside (NR) could increase NAD levels to support cellular health.

Since then, interest has grown in NAD and its intermediates, NR and NMN, for their potential to ameliorate a number of age-related health issues. Low NAD levels have been linked to health concerns and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss. Interestingly, animal research has found that raising NAD levels may help reverse signs of aging and lower the risk of many chronic diseases.

In-depth article and information to follow!

TRU Niagen California Gold Nutrition, NMN Flavonoid Complex For my NR supplementation, I strongly prefer the original TRU NIAGEN for cellular health. I take this in the morning. Additionally, in the evening, I take the NMN Flavonoid Complex from California Gold Nutrition.




Pterostilbene

Pterostilbene, is a natural compound related to resveratrol and found in blueberries, grapes, and certain tree woods. Originally discovered as a component in traditional Asian medicine, it gained more recognition due to its similarities to resveratrol and its superior bioavailability and bioactivity compared to its counterpart. This compound's history traces back to scientific research exploring its antioxidant, anti-inflammatory, and potential anti-aging properties.

Pterostilbene exhibits significant promise in various areas, such as potentially supporting cardiovascular health by improving cholesterol levels and lowering blood pressure. Additionally, it may aid in managing blood sugar levels by enhancing insulin sensitivity and reducing oxidative stress, showing promise for individuals dealing with diabetes or metabolic syndrome. Its neuroprotective effects also suggest potential in supporting brain health by safeguarding against age-related cognitive decline and promoting memory and mental acuity. Moreover, some research indicates its role in potentially inhibiting certain cancer cell growth, although more extensive studies are required to confirm its efficacy.

As a dietary supplement, pterostilbene is available in capsule or powder form, and its use continues to grow as people seek natural means to support overall health and well-being. However, like with other polyphenols, researchers don’t fully understand how pterostilbene works. As Dr. Jose M. Estrela, a professor of physiology at the University of Valencia, Spain who has studied pterostilbene says "the good thing is that pterostilbene works, but the bad thing is that we cannot fully explain its potential health benefits with the information that we have."

In-depth article and information: Resveratrol & Pterostilbene, Effects on Longevity.

Jarrow Formulas, Trans-Pterostilbene There are several viable options for pterostilbene, also in combination with resveratrol - for now, I have settled on the Jarrow Formulas 50mg Trans-Pterostilbene capsules, taking one of them in the morning and another one in the evening. I am debating switching back to a product that contains both pterostilbene and resveratrol, which I used to take in the past, and might do so eventually.




Multi Collagen Complex

Multi-collagen complexes containing types I, II, III, V, and X represent a comprehensive blend of collagen varieties sourced from diverse animal sources, each offering unique benefits to human health. Collagen, the most abundant protein in the human body, is essential for maintaining the structure, strength, and elasticity of connective tissues, skin, bones, and more. The inclusion of multiple collagen types - like type I, found in skin, tendons, and bones; type II, prominent in cartilage; type III, in skin and blood vessels; type V, a component of cell surfaces and hair; and type X, present in forming new bone - creates a more comprehensive supplement.

Collagen supplementation dates back centuries, originating in ancient cultures that utilized animal parts to enhance joint health, skin elasticity, and overall vitality. Today, multi-collagen complexes are utilized as a supplement to support joint health, improve skin elasticity and hydration, aid in bone strength, and contribute to overall connective tissue health.

In-depth article and information: Collagen, Vitamin C and Healthy Skin.

Codeage, Multi Collagen Protein Capsules The Multi Collagen - Type I, II, III, V, X from Codeage is one of the few products that I found from a reputable brand that offers this broad spectrum of collagen. There are others, but they are either from a brand that I don't know and/or come in powder form instead of capsules which isn't something that I want to deal with.
While it would be possible to simply add collagen powder to a protein shake, I find it much more convenient to organize my supplements with pills and capsules.




Vitamin C+

This one probably requires the least explanation. Vitamin C is one of the safest and most effective nutrients, experts say. Though it may not be the cure for the common cold, the benefits of vitamin C may include protection against immune system deficiencies, cardiovascular disease, eye disease, and even skin wrinkling.

I first started taking daily high doses of vitamin C after my PRK laser vision correction. In contrast to the more common and popular LASIK method, PRK (photorefractive keratectomy) surgery is a form of laser vision correction in which a laser eye surgeon completely removes the surface layer of the cornea (i.e. the epithelium, essentially a very thin and transparent layer of skin) and then reshapes the corneal bed with a laser. The main drawback of PRK, compared to LASIK, is that it is a lot more debilitating and takes longer to heal. The main advantage of PRK, compared to LASIK, is that the surface layer of the cornea heals back entirely scar free and the end result is essentially as if the surgery never happened, other than now having perfect 20/20 vision. To support this healing process and the formation of collagen required to regenerate skin, my eye surgeon recommended that I take 1000 mg of vitamin C throughout the day, every day, for 6 months.

In-depth articles and information: Multivitamin Supplements and Longevity & Collagen, Vitamin C and Healthy Skin.

Solgar, Ester-C Plus, Vitamin C
After initially using other, even higher dosed products, I now prefer Solgar Ester-C Plus 500 mg Vitamin C because I found that the Ester-C® calcium ascorbate formulation is extremely well tolerated by my stomach, even when using consistently high doses.




Ginseng Blend - Korean/American/Siberian

Ginseng, a renowned herb that has been used for centuries in traditional medicine, comes in various forms such as Korean, American, and Siberian ginseng, each with distinct properties and historical applications.

Korean ginseng, known as Panax ginseng, holds a prominent place in Eastern medicine and cultural heritage, valued for its adaptogenic qualities that are believed to enhance vitality and overall well-being. American ginseng (Panax quinquefolius) is revered for its milder nature, often sought for its potential to reduce stress and support immune function. Siberian ginseng, technically Eleutherococcus senticosus rather than a true ginseng, is utilized similarly to Korean and American ginseng, lauded for its adaptogenic properties and potential to combat fatigue and stress.

Ginseng's roots trace back to ancient Chinese medicine, where it was regarded as a symbol of health and vitality. Across different cultures, it has been used to address various ailments, ranging from fatigue and stress to immune support and even supporting cognitive functions. As a supplement, ginseng is often consumed in various forms, including capsules, powders, or teas, to harness its potential benefits, such as boosting energy, improving mental clarity, and supporting the body's stress response.

In-depth article and information: Ginseng, the Primordial Longevity Herb.

Organika, Korean Red Ginseng Organika, American White Ginseng Organika, Siberian Tiger Ginseng I tried a variety of different types and combinations of Ginseng.
I usually take Korean Red Ginseng in the morning and, currently, Siberian Tiger Ginseng in the evening - sometimes I switch things up a little and take American White Ginseng in the evening instead.
All the Ginseng products I currently use are made by Organika.




Omega-3 & Coenzyme Q10

Combining omega-3 fatty acids and coenzyme Q10 (CoQ10) represents a fusion of two influential components with diverse health benefits.

Omega-3 fatty acids have a rich history in the realm of nutritional supplements, renowned for their cardiovascular and cognitive advantages. Derived primarily from fish oil, and sometimes from flaxseed or certain nuts, omega-3s are celebrated for their anti-inflammatory properties and contributions to heart health and brain function.

CoQ10, an antioxidant naturally produced by the body, has gained attention for its role in cellular energy production. Over time, researchers and health enthusiasts have recognized the potential synergy between omega-3s and CoQ10, often combined in supplements to amplify their respective benefits. This combination is believed to support heart health, augment cellular energy production, and bolster antioxidant capabilities, potentially aiding in managing and preventing conditions like high blood pressure, heart disease, and promoting overall vitality.

In-depth article and information: Omega-3 & CoQ10, Effects on Longevity.

Webber Naturals, Omega-3 with CoQ10 Nothing too fancy or special here; I find Webber Naturals Omega-3 with CoQ10 to be a very solid product. Yes, the capsules are large, like basically all fish oil capsules, but easy to swallow and without any fishy aftertaste.




N-Acetyl-L-Cysteine & Liver Health

N-acetyl-L-cysteine (NAC) is a compound that has gained recognition in the realm of health supplements and nootropics due to its multifaceted properties. Originating as a derivative of the naturally occurring amino acid cysteine, NAC has a storied history, initially finding its place in the medical field for its role as a mucolytic agent, helping to break down mucus. Over time, researchers began exploring its broader therapeutic potential beyond respiratory issues.

NAC's uses as a supplement expanded to encompass its antioxidant properties, supporting liver health, and its influence on brain function. As a nootropic, NAC has shown promise in promoting mental wellness - its ability to modulate glutamate levels in the brain contributes to its recognition for potentially improving mood, controlling impulsivity, and reducing symptoms associated with certain neurological disorders. Moreover, NAC's antioxidant nature is thought to protect the brain from oxidative stress, which could help safeguard against age-related cognitive decline.

Additionally, NAC may reduce heart disease risk by reducing oxidative damage to tissues in the heart. It has also been shown to increase nitric oxide production, which helps veins dilate and improves blood flow. This expedites blood transit back to the heart and can lower the risk of heart attacks.

In-depth article and information: N-Acetyl-L-Cysteine as a Dietary Supplement.

Source Naturals, NAC
Webber Naturals, Liver Health I currently use the NAC product from Source Naturals. It provides a high dose of NAC although as a result the capsules are quite large, which is something I used to dislike, but I've gotten used to them, they have a coating that makes them easy to swallow, and I only take them in the morning on weekends - not too bad. My multivitamin of choice also contains a small dose of NAC for daily intake.
Related to this topic, I am also taking the Liver Health product from Webber Naturals in the evening on a daily basis.




Nootropic Complex

Nootropics, often referred to as "smart drugs" or "cognitive enhancers", encompass a diverse range of substances known for their potential to improve cognitive function, memory, creativity, motivation, and overall brain performance. The concept of nootropics dates back to the 1960s when Romanian psychologist and chemist Dr. Corneliu E. Giurgea coined the term. He defined nootropics as compounds that could enhance learning and memory without causing significant side effects.

These substances are believed to work by influencing neurotransmitters, enzymes, and other factors related to brain function. Over time, nootropics have gained popularity due to their potential to support mental clarity and focus, particularly among individuals seeking improved productivity, students aiming to enhance learning capabilities, professionals navigating demanding workloads, and even older adults interested in maintaining cognitive health.

The uses of nootropics vary widely, with a spectrum of compounds categorized as natural (such as caffeine and certain herbs) to synthetic substances (like racetams and modafinil). Natural nootropics like caffeine and L-theanine, found in tea, are known for their stimulating and calming effects, respectively. Meanwhile, synthetic nootropics like racetams are thought to modulate neurotransmitter activity, potentially enhancing memory and cognitive functions. Additionally, adaptogens such as Rhodiola and Ashwagandha are believed to help the body adapt to stress and improve mental performance. Some nootropics also focus on specific neurotransmitters, like dopamine or acetylcholine, to support mood, motivation, and memory.

In-depth article and information to follow!

IRON KINGDOM, ebrain
Jarrow Formulas, Methyl B-12
Previously, all supplements on my plan were heavily weighted towards the physical and I wanted to add a product that would balance that out with the mental. After spending a lot of time researching nootropics and trying a few things, I decided on ebrain from Iron Kingdom. It offers a comprehensive blend of substances, however, I only take 1 capsule during weekdays instead of the recommended serving size of 4. I'm more interested in the effects of regular long-term use than a short-term boost to my productivity.
On weekends, I only take a high dose of Vitamin B12 from Jarrow Formulas instead.

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